This study investigated the effects of berberine on amelioration of hyperglycemia and hyperlipidemia and the mechanism involved in high glucose and high fat diet-induced diabetic hamsters.Golden hamsters fedwith high glucose and high fat dietweremedicated with metformin, simvastatin, and low or high dose of berberine (50 and 100mg⋅kg−1) for 6 weeks. The results showed that the