Impact of physical activity, ageing, obesity and metabolic syndrome on muscle microvascular perfusion and endothelial metabolism Muscle microvascular blood flow responses in insulin resistance and ageing
Abstract Insulin resistance plays a key role in the development of type 2 diabetes. Skeletal muscle is the major storage site for glucose following a meal and as such has a key role in maintenance of blood glucose concentrations. Insulin resistance is characterised by impaired insulin‐mediated glucose disposal in skeletal muscle. Multiple mechanisms can contribute to